Archive for the ‘Nutrition’ Category

Genomind

Genetic Testing

Genomind

 

The Genecept Assay Test Panel at a Glance

Pharmacodynamic

GENE PHYSIOLOGICAL ROLE IMPACT OF MUTATION TREATMENT IMPACT
Serotonin Transporter
(SLC6A4)
Protein responsible for reuptake of serotonin from the synapse Inhibition of this protein by SSRIs,
which may lead to increased risk for non-response/side effects
Use caution with SSRIs; atypical antidepressants or SNRIs may be used if clinically indicated
Calcium Channel
(CACNA1C)
A subunit of the calcium channel which mediates excitatory signaling Associated with conditions characterized
by mood instability/lability
Atypical antipsychotics, mood stabilizers, and/or
omega-3 fatty acids, which may help to reduce excitatory signaling, may be used if clinically indicated
Sodium Channel
(ANK3)
Protein that plays a role in sodium channel function and regulation of excitatory signaling Associated with conditions characterized
by mood instability/lability
Mood stabilizers and/or omega-3 fatty acids, which may help to reduce excitatory signaling, may be used if clinically indicated
Serotonin Receptor 2C
(5HT2C)
Receptor involved in regulation of satiety Blocked by atypical antipsychotics,
resulting in metabolic side effects
Use caution with atypical antipsychotics; inositol may be used to mitigate risk for weight gain if clinically indicated
Melanocortin 4 Receptor
(MC4R)
Receptor that plays a role in the control of food intake Increased risk for weight gain and higher BMI, which is exacerbated by atypical antipsychotics Use caution with atypical antipsychotics
Dopamine 2 Receptor
(DRD2)
Receptor affected by dopamine in the brain Blocked by antipsychotic medications and is associated with risk for non-response/side effects Use caution with antipsychotics
Catechol-O-Methyltransferase
(COMT)
Enzyme primarily responsible for the degradation of dopamine in the frontal lobes of the brain Altered dopamine states can have emotional/behavioral effects and impact response to dopaminergic agents Dopaminergic agents or TMS may be used if clinically indicated for Val/Val patientsUse caution with dopaminergic agents in
Met/Met patients
Alpha-2A Adrenergic Receptor
(ADRA2A)
Receptor involved in neurotransmitter release Associated with improved response to stimulant agents Stimulant agents may be used if clinically indicated
Methylenetetrahydrofolate Reductase
(MTHFR)
– A1298C
– C677T
Predominant enzyme that converts folic acid/folate to its active form (methylfolate) needed for synthesis of serotonin, dopamine, and norepinephrine Associated with varied activity and conversion of folic acid/folate to methylfolate Supplementation with L-methylfolate may be used if clinically indicated
Brain-derived
Neurotrophic Factor
(BDNF)
Important for proper neuronal development and neural plasticity Impaired BDNF secretion, which may be associated with altered SSRI response in Caucasians Increased physical activity/exercise may be beneficial for Met carriers if clinically indicated
μ-Opioid Receptor
(OPRM1)
Opioid receptor affected by natural and synthetic compounds Activated by opioids and associated with varied analgesic response, dosage, and abuse/addiction risk Use caution with opioids; non-opioid analgesics may be used if clinically indicated
Glutamate Receptor
(GRIK1)
An excitatory neurotransmitter receptor in the brain Associated with response to topiramate for alcohol abuse Topiramate may be used for treatment of alcohol abuse if clinically indicated

 

Pharmacokinetic

GENE PHYSIOLOGICAL ROLE IMPACT OF MUTATION TREATMENT IMPACT
CYP450
(CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4/5)
Enzymes that metabolize medications in the liver Large number of psychiatric medications are metabolized by CYP450s Dose adjustment (an increase or decrease) may be required

 

Please follow and like us:

Cleveland Heart Labs

Learn More about the comprehensive labwork Dr. Jones recommends for our patients!

Home

 

Please follow and like us:

Eat Fat Get Thin

“Everyone seems to be talking about fat these days. That fat somehow is good now and can help with weight loss and disease prevention.  How can that be true when for decades we all were told that fat was the bad guy?” asks this week’s house call. “What are its benefits? Are there any downsides to eating more fat?”

To see full article visit: http://drhyman.com/blog/2015/12/27/separating-fat-from-fiction-10-fat-facts-you-need-to-know/

Please follow and like us:

Perlmutter’s Guide to the Glycemic Index

Perlmutter’s Guide to the Glycemic Index

Whether you are sick, well, overweight, metabolically compromised, experiencing brain issues, or just want to preserve your mental wellbeing, understand that the Glycemic Index plays a pivotal role.  Choose foods with a lower GI while making sure they are gluten-free. This will maintain healthy levels of blood sugar and insulin. These are the keys to enhancing general health as well as brain health and function.

Please follow and like us: