How To Take Adderall (Amphetamine-Dextroamphetamine)

ADDERALL XR (amphetamine-dextroamphetamine)

ADDERALL XR is a mixed salt amphetamine approved by the FDA for treatment of Attention Deficit Hyperactivity Disorder. Mixed salt amphetamines have been studied and used clinically to treat ADHD since the 1930’s.

Amphetamines, as a class of stimulants, increase activity of the brain’s natural stimulants, Dopamine and Norepinephrine. Dopamine regulates interest, motivation, energy, concentration, pleasure seeking and movement. Norepinephrine regulates alertness, focus, energy, and vigilance. Adderall’s effects on Norepinephrine are about equal to its Dopamine effect.

ADDERALL XR comes in 5, 10, 15, 30, 25, and 30 mg slow release capsules. The cost is the same for all 6 sizes. Total duration of effect for the XR form is 7-12 hours. Half of the dose is absorbed immediately, and takes effect in about 30 minutes. Half is absorbed in 4 hours.

ADDERALL tablets (scored) come in 5, 7.5, 10, 12.5, 15, 20, and 30 mg sizes. Duration of action for the tablets is 3 ½ – 6 hours. Tablets are more likely to have rebound side effects, and doses are more likely to be missed or delayed.

Unlike most prescriptions, ADDERALL cannot be called into the pharmacy. By state regulations all stimulants require written prescriptions, which MUST BE FILLED WITHIN SEVEN DAYS. This means a prescription written on Monday must be filled by Sunday.




  • STARTING DOSE is 10mg in am for adults, 5mg in am for children.
  • Increase dose by 10mg every 1-4 days until symptoms are under control.
  • Dosing needs to be individualized for optimal benefit but is in the 20-90 mg range for most people. Maximum total daily dose is usually 2/3’s body weight in pounds. (Do not go above prescribed dose without doctor’s approval.)
  • Higher doses last longer and can be effective up to 10-12 hours.
  • If nervousness or over-stimulation occurs, always REDUCE the dose.


If switching from ADDERALL tablets to capsules (XR), total the daily dose of tablets in mg and take half as often. For example, if currently taking 30mg tablets twice daily, switch to 60mg XR in am (two 30mg XR capsules). If taking 15mg 4x per day, take 30mg XR twice per day.


Most side effects are mild and occur mainly in the first two weeks of starting medication. In studies, very few people stop medication due to side effects. If side effects are experienced to a bothersome degree, decrease the dose.

Side Effect Children <13 Adolescents Adults
Decreased appetite
Emotional lability    
Abdominal pain  
Weight loss  
Dry mouth    

May aggravate tics.

Side effects that peak around 6 hours from dose are most likely due to the medication. Dose needs to be reduced.

Irritability and tiredness/fatigue that occurs more than 6 hours after last dose are more likely due to medication wearing off (rebound effect). Dosing may need to be adjusted by adding an extra dose or by increasing the dose.

Many side effects are well controlled by Tenex (Guanfacine).


Eat a good breakfast 15-30 minutes after the morning dose. A nighttime snack such as ice cream is also recommended. Appetite usually improves over time, but if not, other methods of management can be used. Weight loss is common especially in people who are overweight. This is usually not due to appetite decrease but to a decreased tendency to eat due to boredom or stress.

Tenex may help taken a.m., evening, or both.

Remeron (Mirtazapine) helps sleep and appetite. Start very low (7.5 mg or lower). Remeron can cause morning drowsiness, especially when first starting.


First, shift dose to earlier in the day. If earlier does not work, take dose LATER in day. This may be caused by a “rebound” of ADD symptoms. Sometimes, medications that provide normal sleep are needed.

NOTE: Blood pressure should be monitored especially if any of the following is used on a regular basis with Adderall. Tenex is the first treatment option since it directly counteracts the effects of Adderall and these medications on blood pressure.

  • Caffeine-large amounts
  • Appetite suppressants
  • Thyroid
  • Some asthma meds
  • Wellbutrin XL
  • Effexor XR
  • Tricyclics
  • Cymbalta

For full information, see package insert or prescribing information.

Please follow and like us:

2 Responses to “How To Take Adderall (Amphetamine-Dextroamphetamine)”

  • Jim says:


    I am 22 and have been taking Adderall XR for 5 years with holidays in the summer. The drug has no psychoactive ingredient and cannot cause hallucinations as you have described. You may want to see a neuro-psychologist and figure out what is really going on with your son. As much as it may cost, it is better to be properly evaluated by a professional than let the problem persist.