Vyvanse is a new delivery system for a medication we have used for 70 years. Extra precaution needs to be taken with CV issues like Mitral Valve Prolapse. I’m not aware of a specific study with MVP, but a study was done at Harvard of patients with ADHD and high blood pressure. The blood pressure was gotten under control first – then the patients were treated for ADHD and tolerated stimulants as well as patients with normal blood pressure.
Starting low and going slow would be essential with decreased dose or stopping if you have any side-effects that could be related to the drug, such as palpitations, dizziness, etc.